Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development
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چکیده
منابع مشابه
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
Ubiquitin ligases are critical components of the ubiquitination process that determine substrate specificity and, in collaboration with E2 ubiquitin-conjugating enzymes, regulate the nature of polyubiquitin chains assembled on their substrates. Cellular inhibitor of apoptosis (c-IAP1 and c-IAP2) proteins are recruited to TNFR1-associated signalling complexes where they regulate receptor-stimula...
متن کاملc-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signaling
Thank you again for submitting your manuscript for consideration by The EMBO Journal. It has now been seen by three expert reviewers, whose comments are copied below. As you will see, they all consider your results as a first implication of K11-linked ubiquitin chains in TNF signaling interesting and potentially important and thus in principle suited for publication in The EMBO Journal. Neverth...
متن کاملK11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.
Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncanonical K11-linked chains is less clear. A crystal structure of K11-linked diubi...
متن کاملUBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.
The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial. By using a single-lysine APC substrate to dissect the topology of ubiquitinated substrates, we find th...
متن کاملTGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling
Colorectal cancer (CRC) is one of the most common cancers, but the mechanisms underlying its initiation and progression are largely unknown. TGIF1 (TGFB induced factor homeobox 1) is a transcriptional corepressor that belongs to the three-amino acid loop extension (TALE) superclass of atypical homeodomains. It has been reported that TGIF1 is highly expressed in mammary cancer and non-small cell...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2018
ISSN: 2041-4889
DOI: 10.1038/s41419-018-0451-y